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Where is the chiral carbon located on thalidomide?

1 Answer

Jul 16, 2016

The chiral centre is $"C-3"$ of the 2,6-piperidine-2,6-dione ring.

Explanation:

The structure of thalidomide is

Thalidomide
(From chemwiki.ucdavis.edu)

$"C-3"$ of the piperidine-2,6-dione has four different groups attached:

$"N"$
the carbonyl carbon ( $"C-2"$ of the ring)
the $"CH"_2$ carbon ( $"C-4"$ of the ring)
$"H"$

∴ $"C-3"$ is the chiral carbon.

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