What can Grignard react with?
1 Answer
Typically we react Grignard reagents with carbonyl species.
Explanation:
The best way to make a carboxylic acid is to pour the Grignard reagent onto dry ice:
Grignards will react with aldehydes and ketones to give secondary and tertiary alcohols:
Grignards will react with epoxides to extend the carbon by 2 carbons:
The reaction with alkyl halides is generally unsuccessful. But Grignards will also react with any protic reagent, i.e. alcohols or water:
The water sensitivity of Grignard reagents is the reason why we take considerable precaution to perform these reactions under anhydrous conditions.