How will you prepare propanamine from methyl chloride using suitable reactions?

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Answer 1 · 2016-03-24T23:36:48

How about the sequence below?

1. Convert to a Grignard reagent

#"CH"_3"Br" stackrelcolor(blue)("dry ether"color(white)(m))(→) "CH"_3"MgBr"#

2. React with ethylene oxide

#"CH"_3"MgBr" stackrelcolor(blue)("1. ethylene oxide"color(white)(m))(stackrelcolor(blue)("2. H"^+color(white)(mmmmmml))(→)) "CH"_3"CH"_2"CH"_2"OH"#

3. Convert to the chloride

#"CH"_3"CH"_2"CH"_2"OH" stackrelcolor(blue)("PCl"_3color(white)(m))→ "CH"_3"CH"_2"CH"_2"Cl"#

4. React with #"NH"_3#

#"CH"_3"CH"_2"CH"_2"Cl" stackrelcolor(blue)("NH"_3color(white)(m))(→) "CH"_3"CH"_2"CH"_2"NH"_2#