How do you perform a Williamson ether synthesis?
1 Answer
Feb 14, 2017
Use an alkoxide ion (formed from an alcohol) and alkyl halide or tosylate. Mechanism involves
Explanation:
The Williamson ether synthesis is the most reliable and versatile ether synthesis. This method involves the
General mechanism:
Note that the alkoxide is commonly made by adding Na, K, or NaH to an alcohol.
Wade, L. G., Simek, J. W. Organic chemistry, global edition, 9th ed.; Pearson Education Limited: Glenview, IL, 2016, pg 682.