Do E1 reactions require a strong base, like E2 reactions?

1 Answer
Ernest Z.
Nov 14, 2014

No. The base is not involved in the rate determining step, so the nature of the base is unimportant in an "E"1E1 reaction.

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But, the stronger the base, the more likely an "E"2E2 reaction becomes.

"E"2E2 reactions always involve a strong base. They need chemicals strong enough to pull off a weakly acidic hydrogen atom. These are usually charged bases like C₂H₅O⁻ and (CH₃)₃CO⁻.

Uncharged bases like H₂O, C₂H₅OH and (CH₃)₃COH are too weak to remove weakly acidic β H atoms.

If the strongest base in your reaction mixture is an uncharged molecule, you will get an "E"1E1 reaction.

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