Question #b6c38

1 Answer
Jan 27, 2018

The classic way would be to make the tolyl sulfonate ester.....

Explanation:

And so....

ROH+Cl(O=)2SC7H8H+,C6H5N−−−−−ROS(=O)2C7H8+HClNC6H5....

The sulfonate is an excellent leaving group that can be displaced by moderate nucleophiles....

When you do these reactions, you will not be a popular man/women. Toluene sulfonyl chlorides have a powerful, penetrating smell of rancid butter...and even with a lot of care, and an efficient hood, your neighbours will come around acomplaining....and you also have to use pyridine...