Question #a86c8
1 Answer
Dec 28, 2016
How about this?
Explanation:
- Nitration of phenol
- Reduction of the nitro group
- Acetylation of the amine
(a) Nitration of phenol
The
The 2-nitrophenol is removed by steam distillation.
The 4-nitrophenol is filtered off and purified by recrystallization.
(b)
The 4-nitrophenol is reduced to 4-aminophenol at 15 °C by
(c) Acetylation of 4-aminophenol to paracetamol
The 4-aminophenol is acetylated with acetic anhydride and water at room temperature.
The crude paracetamol is recrystallized from water.