What are the rules for defining E-Z configuration?

1 Answer
Mar 4, 2018

Consider two alkenes,

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This is very reminiscent of the R and S configuration assignments. We find an double bond that has a few different substituents, such as those above.

In the former molecule, it's Z since the highest priority substituents are on the same side of double bond.

In the latter molecules, it's E since the highest priority substituents are on different sides of the double bond.

It's very straightforward compared when you first learned absolute configuration!