Please solve this phenol reaction based problem?

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Please solve this phenol reaction based problem?

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Answer 1 · 2018-03-25T19:35:03

Well, it depends on how much excess... If we want to not waste money, then only the top $OH$ $"OH"$ will react... by a thermodynamic factor of about $10^{4}$ $10^4$ over the other one reacting.

The ${pK}_{a}$ $"pK"_a$ of protonated phenol is about $- 6$ $-6$ , and that of protonated ethanol is about $- 2.4$ $-2.4$ . Hence, protonating the top $OH$ $"OH"$ is favored by a factor of $10^{- 2.4 - (- 6)}$ $10^(-2.4-(-6))$ .

Then we just make the Grignard reagent... provided that the experiment is done properly. Water came off of the protonated alcohol, and must be dried off before reacting with $Mg$ $"Mg"$ and dry diethyl ether.

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Please solve this phenol reaction based problem?

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